The KvLm Potassium Channel in Asymmetric Bilayer
نویسندگان
چکیده
منابع مشابه
An evidence for a potassium channel in endoplasmic reticulum based on single channel recording in bilayer lipid membrane
Introduction Numerous studies have demonstrated the presence of potassium selective channels in membranes internal organelles. These channels are essential to a large variety of cellular processes including intracellular 2+ a signaling, protein recycling, charge neutralization and cell protection. In contrast to the sarcoplasmic reticulum + here potassium channels have been clearly ...
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Many pharmaceutical drugs against neurological and cardiovascular disorders exert their therapeutic effects by binding to specific sites on voltage-gated ion channels of neurons or cardiomyocytes. To date, all molecules targeting known ion channel sites bind to protein pockets that are mainly surrounded by water. We describe a lipid-protein drug-binding pocket of a potassium channel. We synthes...
متن کاملan evidence for a potassium channel in endoplasmic reticulum based on single channel recording in bilayer lipid membrane
introduction numerous studies have demonstrated the presence of potassium selective channels in membranes internal organelles. these channels are essential to a large variety of cellular processes including intracellular 2+ a signaling, protein recycling, charge neutralization and cell protection. in contrast to the sarcoplasmic reticulum + here potassium channels have been clearly identified, ...
متن کاملAn evidence for a potassium channel in endoplasmic reticulum based on single channel recording in bilayer lipid membrane
Introduction Numerous studies have demonstrated the presence of potassium selective channels in membranes of internal organelles. These channels are essential to a large variety of cellular processes including intracellular Ca2+ signaling, protein recycling, charge neutralization and cell protection. In contrast to the sarcoplasmic reticulum where potassium channels have been clearly identified...
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Potassium channels enable K(+) ions to move passively across biological membranes. Multiple nanosecond-duration molecular dynamics simulations (total simulation time 5 ns) of a bacterial potassium channel (KcsA) embedded in a phospholipid bilayer reveal motions of ions, water, and protein. Comparison of simulations with and without K(+) ions indicate that the absence of ions destabilizes the st...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2009.11.038